{"id":4106,"date":"2020-02-07T08:59:03","date_gmt":"2020-02-07T08:59:03","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=4106"},"modified":"2023-08-03T10:20:52","modified_gmt":"2023-08-03T10:20:52","slug":"human-leukocyte-antigen-hla","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/human-leukocyte-antigen-hla\/","title":{"rendered":"Human leukocyte antigen (HLA)"},"content":{"rendered":"

The human major histocompatibility complex composed of both MHC class I and MHC class II molecules, present in all nucleated mammalian cells. Primarily responsible for graft rejection between individuals.<\/p>\n

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A very complex array of six proteins that cover the surface of leukocytes (and the bone marrow cells that produce leukocytes). These HLA are usually different (i.e., a non-match) for individuals that are not genetically related to each other (e.g., a father-son or a father-daughter), so have been used in the past to prove paternity. HLA must also be matched (as nearly as possible) for successful bone marrow transplants, to prevent the donated bone marrow (and the marrow recipient) from “rejecting” each other.<\/p>\n

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Protein markers of self used in histocompatibility testing. Some types are also correlated with certain autoimmune diseases.<\/p>\n

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A blood component which can be “typed” in order to determine the compatibility of the bloods of two individuals.<\/p>\n

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In the realm of bone marrow cells, there exists a collection of protein molecules capable of inciting an immune response. It is crucial for the HLA types of both the donor and recipient to closely align in order to minimize the risk of the recipient’s immune system launching an assault on the donor’s marrow. This precautionary measure ensures that the recipient’s body does not perceive the donor’s marrow as an alien substance that does not harmonize with its natural composition.<\/p>\n

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A protein that is part of the histocompatibility antigens group of proteins, contributing to the functioning of the immune system.<\/p>\n

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The human major histocompatibility complex composed of both MHC class I and MHC class II molecules, present in all nucleated mammalian cells. Primarily responsible for graft rejection between individuals. A very complex array of six proteins that cover the surface of leukocytes (and the bone marrow cells that produce leukocytes). These HLA are usually different […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-4106","post","type-post","status-publish","format-standard","hentry","category-h"],"yoast_head":"\nHuman leukocyte antigen (HLA) - Definition of Human leukocyte antigen (HLA)<\/title>\n<meta name=\"description\" content=\"The human major histocompatibility complex composed of both MHC class I and MHC class II molecules, present in all nucleated mammalian cells. Primarily responsible for graft rejection between individuals.A very complex array of six proteins that cover the surface of leukocytes (and the bone marrow cells that produce leukocytes). These HLA are usually different (i.e., a non-match) for individuals that are not genetically related to each other (e.g., a father-son or a father-daughter), so have been used in the past to prove paternity. HLA must also be matched (as nearly as possible) for successful bone marrow transplants, to prevent the donated bone marrow (and the marrow recipient) from "rejecting" each other.Protein markers of self used in histocompatibility testing. Some types are also correlated with certain autoimmune diseases.A blood component which can be "typed" in order to determine the compatibility of the bloods of two individuals.In the realm of bone marrow cells, there exists a collection of protein molecules capable of inciting an immune response. It is crucial for the HLA types of both the donor and recipient to closely align in order to minimize the risk of the recipient's immune system launching an assault on the donor's marrow. This precautionary measure ensures that the recipient's body does not perceive the donor's marrow as an alien substance that does not harmonize with its natural composition.A protein that is part of the histocompatibility antigens group of proteins, contributing to the functioning of the immune system.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/human-leukocyte-antigen-hla\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human leukocyte antigen (HLA) - Definition of Human leukocyte antigen (HLA)\" \/>\n<meta property=\"og:description\" content=\"The human major histocompatibility complex composed of both MHC class I and MHC class II molecules, present in all nucleated mammalian cells. Primarily responsible for graft rejection between individuals.A very complex array of six proteins that cover the surface of leukocytes (and the bone marrow cells that produce leukocytes). These HLA are usually different (i.e., a non-match) for individuals that are not genetically related to each other (e.g., a father-son or a father-daughter), so have been used in the past to prove paternity. HLA must also be matched (as nearly as possible) for successful bone marrow transplants, to prevent the donated bone marrow (and the marrow recipient) from "rejecting" each other.Protein markers of self used in histocompatibility testing. Some types are also correlated with certain autoimmune diseases.A blood component which can be "typed" in order to determine the compatibility of the bloods of two individuals.In the realm of bone marrow cells, there exists a collection of protein molecules capable of inciting an immune response. 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