{"id":6109,"date":"2020-02-14T07:31:58","date_gmt":"2020-02-14T07:31:58","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=6109"},"modified":"2020-02-14T07:31:58","modified_gmt":"2020-02-14T07:31:58","slug":"osteoclastogenesis","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/osteoclastogenesis\/","title":{"rendered":"Osteoclastogenesis"},"content":{"rendered":"<p>Mechanism of osteoclast generation through differentiation of precursor cells of the hematopoietic lineage induced by regulatory molecules. Calcitropic factors, such as vitamin D3, prostaglandin E2, interleukin\u20101, interleukin\u20102, tumor necrosis factor, and glucocorticoid induce receptor activator nuclear factor\u2010kappa ligand (RANKL) expression on osteoblasts. RANKL binding to the RANK expressed on hematopoietic progenitors activates a signal transduction cascade that leads to osteoclast differentiation in the presence of the survival factor colony\u2010stimulating factor 1.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mechanism of osteoclast generation through differentiation of precursor cells of the hematopoietic lineage induced by regulatory molecules. Calcitropic factors, such as vitamin D3, prostaglandin E2, interleukin\u20101, interleukin\u20102, tumor necrosis factor, and glucocorticoid induce receptor activator nuclear factor\u2010kappa ligand (RANKL) expression on osteoblasts. RANKL binding to the RANK expressed on hematopoietic progenitors activates a signal transduction [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-6109","post","type-post","status-publish","format-standard","hentry","category-o"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Osteoclastogenesis - Definition of Osteoclastogenesis<\/title>\n<meta name=\"description\" content=\"Mechanism of osteoclast generation through differentiation of precursor cells of the hematopoietic lineage induced by regulatory molecules. Calcitropic factors, such as vitamin D3, prostaglandin E2, interleukin\u20101, interleukin\u20102, tumor necrosis factor, and glucocorticoid induce receptor activator nuclear factor\u2010kappa ligand (RANKL) expression on osteoblasts. RANKL binding to the RANK expressed on hematopoietic progenitors activates a signal transduction cascade that leads to osteoclast differentiation in the presence of the survival factor colony\u2010stimulating factor 1.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/osteoclastogenesis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Osteoclastogenesis - Definition of Osteoclastogenesis\" \/>\n<meta property=\"og:description\" content=\"Mechanism of osteoclast generation through differentiation of precursor cells of the hematopoietic lineage induced by regulatory molecules. Calcitropic factors, such as vitamin D3, prostaglandin E2, interleukin\u20101, interleukin\u20102, tumor necrosis factor, and glucocorticoid induce receptor activator nuclear factor\u2010kappa ligand (RANKL) expression on osteoblasts. 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