{"id":92292,"date":"2021-03-23T07:18:03","date_gmt":"2021-03-23T07:18:03","guid":{"rendered":"https:\/\/www.healthbenefitstimes.com\/glossary\/?p=92292"},"modified":"2022-09-06T10:25:20","modified_gmt":"2022-09-06T10:25:20","slug":"letterer-siwe-disease","status":"publish","type":"post","link":"https:\/\/www.healthbenefitstimes.com\/glossary\/letterer-siwe-disease\/","title":{"rendered":"Letterer-siwe disease"},"content":{"rendered":"

A usually fatal disease, most common in infants, caused by the overproduction of a specialised type of immune cell.<\/p>\n

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The most common of three distinct histiocytosis syndromes collectively known as Langerhans cell histiocytosis, marked by proliferation of histiocytes in the viscera, bones, and skin. It is believed that this disease and the other two forms \u2014 eosinophilic granuloma of bone and Hand-Schiiller-Christian syndrome \u2014 share a common pattern of granulomatous lesions with histiocyte proliferation.<\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

A usually fatal disease, most common in infants, caused by the overproduction of a specialised type of immune cell. The most common of three distinct histiocytosis syndromes collectively known as Langerhans cell histiocytosis, marked by proliferation of histiocytes in the viscera, bones, and skin. It is believed that this disease and the other two forms […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-92292","post","type-post","status-publish","format-standard","hentry","category-l"],"yoast_head":"\nLetterer-siwe disease - Definition of Letterer-siwe disease<\/title>\n<meta name=\"description\" content=\"A usually fatal disease, most common in infants, caused by the overproduction of a specialised type of immune cell.The most common of three distinct histiocytosis syndromes collectively known as Langerhans cell histiocytosis, marked by proliferation of histiocytes in the viscera, bones, and skin. It is believed that this disease and the other two forms \u2014 eosinophilic granuloma of bone and Hand-Schiiller-Christian syndrome \u2014 share a common pattern of granulomatous lesions with histiocyte proliferation.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.healthbenefitstimes.com\/glossary\/letterer-siwe-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Letterer-siwe disease - Definition of Letterer-siwe disease\" \/>\n<meta property=\"og:description\" content=\"A usually fatal disease, most common in infants, caused by the overproduction of a specialised type of immune cell.The most common of three distinct histiocytosis syndromes collectively known as Langerhans cell histiocytosis, marked by proliferation of histiocytes in the viscera, bones, and skin. 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