Renin

A proteolytic enzyme that is secreted by the juxtaglomerular cells of the kidney. Its release is stimulated by decreased arterial pressure and renal blood flow resulting from decreased extracellular fluid volume. It catalyzes the formation of angiotensin I from hypertensinogen. Angiotensin I is then converted to angiotensin II by another enzyme located in the endothelial cells of the lungs. Angiotensin II then causes the increase in the force of the heartbeat and constricts the arterioles. This scenario causes a rise in the blood pressure and is thus a cause of hypertension (high blood pressure).

An enzyme that is released from the kidney into the circulation and generates angiotensin I (an inactive substance), which is then converted into angiotensin, a powerful constrictor of arteries and arterioles that can elevate blood pressure.

A hormone produced by the kidneys, which is important in regulating normal blood pressure.

An enzyme secreted by the kidney to prevent loss of sodium, and which also affects blood pressure.

An enzyme that initiates the cascade that generates angiotensin II and III.

Enzyme released by the kidney that affects blood pressure by catalyzing the formation of angiotensin I from angiotensinogen; angiotensin converting enzyme then converts angiotensin I to angiotensin II, a potent vasoconstrictor and stimulant of sodium and water retention. Angiotensin III is the final metabolically active product and is a strong stimulant of aldosterone secretion.

Enzyme released by the juxtaglomerular cells when there is a drop In renal blood flow that converts angiotensin to constrict blood vessels and maintain blood pressure.

An enzyme released into the blood by the kidney in response to stress. Renin reacts with the liver to produce angiotensin, which eventually causes constriction of the blood vessels and an increase in blood pressure. It is estimated that 10 to 15 percent of people with high blood pressure have too much renin in their blood. The overproduction of renin can occur from a condition called renal (kidney) hypertension.

A substance released into the blood by the kidney in response to stress. It reacts with a substrate from the liver to produce angiotensin, which causes constriction of blood vessels and thus an increase in blood pressure. Excessive production of renin results in the syndrome of renal hypertension.

The enzyme produce by the kidneys and released into the blood in response to stress. Renin reacts to the compound produced by the liver to produce angiotensin. This cause blood vessels to constrict and raise the blood pressure. If too much renin is produced, this results in renal hypertension.

An enzyme produced by the kidney that splits angiotensinogen to form angiotensin I, which is then transformed to angiotensin II, which stimulates vasoconstriction and secretion of aldosterone. The blood renin level is elevated in some forms of hypertension.

In the realm of renal physiology, an endogenous catalyst synthesized within the intricate structures of the kidneys assumes the pivotal role of regulating the initiation of the esteemed hormone known as angiotensin. This hormonic entity, in turn, imparts its stimulating influence upon the adrenal glands, coaxing them into a state of heightened productivity, specifically geared towards the synthesis and secretion of a vital corticosteroid known as aldosterone.