A bone‐specific protein produced by the osteoblast which may play a role in osteoclast recruitment, found in the extracellular matrix of bone, dentin, and the serum of circulating blood. A marker for bone remodeling or mineralization. This vitamin K‐dependent, calcium‐binding protein is produced by osteoblasts and is the most abundant noncollagen protein in bone. Because of calcium‐binding sites, it plays a role in bone matrix mineralization or in regulation of crystal growth. In addition, its increased serum concentration is a marker of increased bone turnover in disease states (e.g., Paget’s disease or postmenopausal osteoporosis). It has a low molecular weight and contains three alpha‐carboxyglutamic acid residues per molecule. Called also gammalinolenic acid (GLA) protein.
A noncollagenous protein found in bone and dentin, also refer to as bone gammacarboxyglutamic acid-containing protein.
A calcium-binding protein in bone, essential for the normal mineralisation of bone. Its synthesis requires vitamin K, and is controlled by vitamin D.
A protein whose synthesis is dependent on vitamin K and which acts to promote mineral deposition in bone. This protein contains numerous glutamic acid residues, which are carboxylated post-translationally through the action of the vitamin K-dependent epoxide cycle.