Enzyme derepression

Commonly known as induction (of an enzyme). Initially a repressor protein is bound to a specific region of DNA. This binding inhibits transcription to mRNA, thus blocking the synthesis of the protein (enzyme) specified by the mRNA. When present, the inducer molecule binds to the repressor protein and inactivates it. Thus the inhibition caused by the repressor protein is overcome and mRNA can be synthesized, which consequently leads to synthesis of the mRNA-specified protein (enzyme). The word derepression is sometimes used because the repressor protein is, by itself, active in repressing protein (enzyme) synthesis. Its repressive action is mitigated (derepressed) by the inducer molecule. Hence, derepression (or unrepression) of repression equals induction.


 


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