Erythropoietin (EPO)

Ahormone produced by the kidney that promotes the formation of red blood cells (erythrocytes) in the bone marrow.


Elormone that controls erythropoiesis (red blood cell production) in the bone marrow.


A glycoprotein hormone produced in the kidneys that stimulates stem cells in the bone marrow to increase the number of red blood cells. Erythropoietin can be used to help correct a variety of anemias.


A glycoprotein hormone produced in the kidneys that stimulates stem cells in the bone marrow to increase the number of red blood cells. Erythropoietin can be used to help correct a variety of anemias.


A hormone produced by the kidneys that controls red blood cell production.


A hormone which regulates the production of red blood cells.


Substance that stimulates red cell formation.


Protein produced by the kidneys and liver that stimulates the bone marrow to produce red blood cells (erythrocytes). Since only 15% of the body’s erythropoietin is manufactured by the liver, a patient with kidney failure inevitably becomes anemic. The gene for this hormone has been cloned and recombinant (genetically engineered) erythropoietin produced in animal cells is available for clinical use. It has also been used illegally in athletes seeking a competitive advantage.


A glycoprotein hormone released into the bloodstream in response to hypoxia which increases the production of red blood cells; also a hormone secreted by the kidney that stimulates the bone marrow to produce red blood cells.


A protein secreted by the kidney that stimulates formation of red blood cells in the bone marrow. Erythropoietin is used to increase the number of red blood cells in people with chronic kidney disease or those with other diseases that affect the ability of the bone marrow to make red blood cells. Erythropoietin is also used to counteract the tendency of some anticancer drugs to suppress bone marrow.


A hormone secreted by certain cells in the kidney in response to a reduction in the amount of oxygen reaching the tissues. Erythropoietin increases the rate of red cell production (erythropoiesis) and is the mechanism by which the rate of erythropoiesis is controlled.


The protein, produced mainly in the kidney, that is the major stimulus for the production of erythrocytes, or red blood corpuscles. It is used when treating anaemia due to end-stage kidney failure and in premature newborns with anaemia.


A cytokine made by the kidneys that stimulates the proliferation of red blood cells. Synthetic erythropoietin (epoetin alfa) is used to treat anemia, especially in patients with renal or bone marrow failure. Hypertension is a common side effect of the drug.


 


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