Gestational trophoblastic disease

A group of pregnancy-related conditions in which abnormal growths develop inside the uterus from abnormal placental tissue. The conditions include a hydatidiform mole, a type of tumor, and the cancer choriocarcinoma, both of which involve trophoblasts, cells that make up one of the layers of the placenta. Symptoms include vaginal bleeding and excessive morning sickness early in pregnancy. The doctor may find that the uterus is larger than expected for the stage of the pregnancy, and there may be no detectable fetal heartbeat.


Any of several neoplastic diseases of the fetal chorion, including complete and partial hydatidiform mole, chorioadenoma destruens, and choriocarcinoma. Sudden rapid uterine enlargement and early second-trimester vaginal bleeding characterize all forms of GTD. Other common signs include hvperemesis gravidarum, pregnancy-induced hypertension before 24 weeks’ gestation, vaginal discharge of hydropic vesicles, and an absence of fetal heart tones.


An uncommon, vigorous, malign neoplasm, frequently metastatic, affecting women in their reproductive years, wherein cancerous cells proliferate within the uterine tissues formed subsequent to conception.


 


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