A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
A colony stimulating factor (CSF; a protein) that stimulates production of granulocytes, particularly neutrophils.
A naturally occurring cytokine glycoprotein that stimulates the proliferation and functional activity of neutrophils. It is effective in treating bone marrow deficiency following cancer chemotherapy or bone marrow transplantation. The generic name is filgrastim.