A condition in which ketones, or abnormal products of fat metabolism, accumulate in the blood.
High concentrations of ketone bodies in the blood.
An abnormal increase in ketone production and accumulation in the blood; occurs especially in protein-sparing diets or fasting.
An excessive accumulation of ketone bodies caused by accelerated rate of tissue lipolysis.
A state in which ketone bodies such as acetone and acetic acid accumulate in the tissues, a late complication of Type I diabetes mellitus.
Ketosis occurs when the rate of ketone production is greater than the rate of ketone catabolism. Ketone synthesis can be increased by many factors including starvation, a low carbohydrate diet, uncontrolled diabetes mellitus, and ingestion of large amounts of medium-chain triglycerides (MCT). In each of the first three, carbohydrate is unavailable for the production of pyruvate, which can produce oxaloacetate. Oxaloacetate is the 4-carbon molecule that accepts the two acetate carbons of acetyl CoA to begin Krebs cycle. Decreased production of oxaloacetate leads to acetyl CoA accumulation, which results in the production of acetoacetyl CoA from the joining of two acetyl CoA molecules. Acetoacetyl CoA produces the ketoacid acetoacetate, which produces acetone (a ketone) and beta-hydroxybutyrate (another ketoacid). MCT ingestion can also promote ketosis, especially when fed as part of a low carbohydrate diet, since medium-chain fatty acids are primarily converted to ketones upon delivery to the liver following absorption.
Abnormal accumulation of ketones in the body, resulting from inadequate intake or metabolism of carbohydrates and increased fatty acid metabolism, leading to the formation of ketone bodies. Ketosis occurs most often in starvation and uncontrolled diabetes mellitus. It is characterized by a fruity breath odor and the presence of ketone bodies in the urine; if untreated, it can lead to ketoacidosis, coma, and death.
An abnormal accumulation of ketones in the body caused by a deficiency or the inefficient use of carbohydrates. Ketones are a by-product of the metabolism of fatty acids. Ketosis occurs when glucose is unavailable for use as a source of energy, and the body instead uses fats, resulting in fatty acids being released into the blood where they are converted to ketones.
Raised levels of ketone bodies in the body tissues. Ketone bodies are normal products of fat metabolism and can be oxidized to produce energy. Elevated levels arise when there is an imbalance in fat metabolism, such as occurs in diabetes mellitus or starvation. Ketosis may result in severe acidosis.
A condition in which an excessive amount of ketones are produced by the body and accumulate in the bloodstream. The affected person becomes drowsy, suffers a headache, breathes deeply, and may lapse into a coma. The condition results from an unbalanced metabolism of fat, which may occur in diabetes mellitus or starvation.
The accumulation in the body of the ketone bodies: acetone, betahydroxybutyric acid, and acetoacetic acid. It is frequently associated with acidosis. Ketosis results from the incomplete metabolism of fatty acids, usually from carbohydrate deficiency or inadequate use, and is commonly observed in starvation, high-fat diet, and pregnancy; following ether anesthesia; and most significantly in inadequately controlled diabetes mellitus. Large quantities of these ketone bodies may be eliminated in the urine (ketonuria). Ketosis is easily determined by testing for the presence of ketones in blood specimens.
The human body may enter a perilous state of disequilibrium, known as ketosis, in which high levels of acidic ketone waste products circulate within. Ketosis symptoms can manifest as halitosis, polyuria, interrupted sleep, constipation, nausea, anxiety, and vertigo. As the body clears ketones, it excretes sodium and potassium, leading to dehydration and anomalous heart rhythms. Concurrently, uric acid accumulates, precipitating gout, gouty arthritis, and renal stones.
The condition in which the human body undergoes the metabolic process of breaking down protein and fat to form ketone bodies, which serve as a source of energy when there is a lack of sugar-based fuel in the body, often resulting from a prolonged low-carbohydrate diet.
An anomalous elevation in the quantity of ketones within the body, resulting from the liver’s breakdown of fat into fatty acids and ketone bodies. Ketosis often arises as a typical consequence of low-carbohydrate diets or unmanaged diabetes. Prolonged presence of ketosis can lead to significant harm to the kidneys and liver.
A potentially severe situation in which the body accumulates excessive amounts of compounds known as ketones. These ketones are normal byproducts of fat metabolism; however, they accumulate excessively when body cells are unable to utilize glucose as an energy source. This situation can arise during periods of starvation, persistent vomiting, and untreated diabetes mellitus, where a deficiency of insulin hinders glucose from entering cells. Symptoms consist of breath with a sweet, acetone-like scent, reduced appetite, nausea, and abdominal discomfort. Over time, ketosis can lead to confusion, loss of consciousness, and even death. The approach to treatment centers around addressing the underlying cause.
The state in which ketone bodies are found in the bloodstream, which occurs in conditions associated with acidosis.