Increased levels of high molecular weight proteins (macroglobulins) in the blood; though small amounts of macroglobulins are normally present, increased levels are abnormal and may be due to a number of disease states (e.g., multiple myeloma, lupus, liver cirrhosis).
The presence in the blood of an abnormal form of immunoglobulin-M, produced by a tumor of the lymphocytes.
An abnormally large tongue. It may be due to a congenital defect, such as thyroid deficiency (cretinism); to infiltration of the tongue with amyloid or a tumor; or to obstruction of the lymph vessels.