Mixed connective tissue disorder (MCTD) is one of many rheumatic diseases. Although it shares some similarities with lupus erythematosus and systemic sclerosis, MCTD differs in regard to the autoimmune factors (IgG autoantibodies) implicated (Maddison, 2000). Age of onset ranges from 5 to 80 years. Juvenile MCTD is rare; early identification and treatment can improve the prognosis. Based on current findings, 80% of those affected with MCTD are female (Robinson, 1999). Recent research suggests a particular genetic susceptibility for Mexicans as well as for African Americans.
An autoimmune disorder impacting the connective tissue that provides structural support throughout the body. This condition encompasses characteristics of systemic sclerosis, systemic lupus erythematosus, polymyositis, and rheumatoid arthritis.
Diagnosis of mixed connective tissue disorder involves blood tests detecting antibodies against a cellular protein named ribonucleic protein (RNP). Treatment parallels that of systemic lupus erythematosus, involving corticosteroid medications and immunosuppressant drugs.