A disease where malignant tumours infiltrate the bone marrow.
A malignant disorder of plasma cells, derived from B-lymphocytes. In most patients the bone marrow is heavily infiltrated with atypical, monoclonal plasma cells, which gradually replace the normal cell lines, inducing anaemia, leucopenia, and thrombocytopenia. Bone absorption occurs, producing diffuse osteoporosis. In some cases only part of the immunoglobulin molecule is produced by the tumour cells, appearing in the urine as Bence Jones proteinuria.
An extremely rare and lethal condition with an unknown cause, marked by the growth of numerous tumors in the skeleton that originate from the bone marrow. The most commonly affected bones are, in order: spine, ribs, sternum, skull, scapula, pelvis, clavicle, humerus, and femur. Typically, patients succumb within six months from when symptoms begin, though some have lived for one to two years. This disease is also known as hematogenous myeloma, Kahler’s disease, or plasmacytoma.