The physical and psychological symptoms that result when someone who is dependent on morphine, heroin, or another opiate stops using the substance. Symptoms can vary from person to person but the syndrome usually begins about 6 to 12 hours after the last opiate dose. Symptoms during the first 24 hours include restlessness, watering of the eyes, runny nose, yawning, heavy sweating, goose bumps, restless sleep, and dilation of the pupils. As time passes, these symptoms become more severe.
Physiological responses to abrupt cessation of the use of addictive substances. The symptoms include chills, runny nose, yawning, irritability, insomnia, and cramping. Physical signs of withdrawal include elevated blood pressure, diaphoresis, diarrhea, and muscle spasms. Discomfort peaks at 48 to 72 hr; however, symptoms persist for 7 to 10 days. Treatment includes methadone and psychological support and counseling.