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Functional, metabolic, or structural changes in ischemic heart muscle thought to result from reperfusion to the ischemic areas. Changes can be fatal to muscle cells and may include edema with explosive cell swelling and disintegration, sarcolemma disruption, fragmentation of mitochondria, contraction band necrosis, enzyme washout, and calcium overload. Other damage may include hemorrhage and ventricular…

Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty,…

A disorder in which the bone marrow is replaced by fibrous tissue. Fibrosis of bone marrow, associated with anaemia. A chronic but progressive disease characterized by fibrosis of the bone marrow, which leads to anemia and the presence of immature red and white blood cells in the circulation. Other features include enlargement of the spleen…

Muscular debility; any constitutional anomaly of muscle. A general weakness and dysfunction of the muscles, caused by poor conduction at the motor end plates. Abnormal muscle weakness, the result of disease, as in myasthenia gravis, or inadequate blood circulation to a given area. Muscular weakness and abnormal fatigue.  

Process of generating genetic mutations. It may occur spontaneously or be induced by mutagens. Damage to genes. Induction of a mutation, or change, in a gene.  

Large single cells, either cylindrical or prismatic in shape, that form the basic unit of muscle tissue. They consist of a soft contractile substance enclosed in a tubular sheath. The basic structural unit of muscle.  

Pertaining to a group of 5 or more homologous or partly homologous chromosomes during the zygotene stage of prophase to first metaphasis in meiosis. Having the ability to combine with more than two univalent elements or compounds.  

Adaptation of tumor cells to anticancer drugs in ways that make the drugs less effective. Ability of a living cell to show resistance to a wide variety of structurally and functionally unrelated compounds. The ability of bacteria, viruses, or cancer cells to live and reproduce despite treatment with more than one drug.  

Pertaining to or affecting the mucous membrane and the skin. Referring to both mucous membrane and the skin. To the mucous membrane and the skin. Pertaining to both the mucous membrane and the skin.  

A secretion containing mucopolysaccharides and protein that is the chief constituent of mucus. Viscous mucoprotein secreted in the saliva and throughout the intestinal tract; the main constituent of mucus. Secretions containing mucopolysaccharides. Chief ingredient of mucus; lubricant protecting body surfaces. There exists a protein in saliva that interacts with sugars present in the mouth, leading…