Restrictive dermopathy is a rare, fatal skin disease. The skin of infants with restrictive dermopathy is bright red, tight, and inflexible. In infants who survive for more than 2 weeks, the skin becomes progressively more rigid. These infants are generally born with opened mouths and fixed joints. These infants have few creases and furrows on their skin. Most of these infants are born prematurely at about 31 weeks of gestation, and premature rupture of membranes are characteristic. These infants typically have underdeveloped lungs and generally die from respiratory failure or septicemia.