Retroviruses (from the Latin word retrovir, which means “backward man”)

Oncogenic (i.e., cancer-producing), single-stranded, diploid RNA (ribonucleic acid) viruses that contain (+) RNA in their virions and propagate through a double-helical DNA intermediate. They are known as retroviruses because their genetic information flows from RNA to DNA (reverse of normal). That is, the viruses contain an enzyme that allows the production of DNA using RNA as a template. Retroviruses can only infect cells in which DNA is replicating, such as tumor cells (since they are constantly replicating) or cells comprising the lining of the stomach (since that lining must replace itself every few days).


 


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