Tetracycline bone labeling

Permanent labeling of osteoid (bone matrix) as it mineralizes in a two‐phase process. With up to 80% of complete mineral uptake regulated by osteoblasts, the remaining 20% is regulated by osteocytes. The osteoid zone is separated from the mineralized part of the bone by a layer called the mineralization front. This layer is able to bind tetracycline, resulting in a permanent fluorescent line.


 


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