The ability to endure or be less responsive to a stimulus over a period of continued exposure.
The power of resisting the action of a poison or of taking a drug continuously or in large doses without injurious effect.
Decreasing response to continued use of the same dose of a drug.
The ability to endure unusually large doses of a drug or toxin.
Acquired drug tolerance; a decreasing response to repeated constant doses of a drug or the need for increasing doses to maintain a constant response.
A characteristic of substance dependence that may be shown by the need for markedly increased amounts of the substance to achieve intoxication or the desired effect, by markedly diminished effect with continued use of the same amount of the substance, or by adequate functioning despite doses or blood levels of the substance that would be expected to produce significant impairment in a casual user.
The ability of the body to tolerate a substance or an action.
The body getting used to a drug; causes the body to need more of the drug to get the same effect.
The acquired phenomenon associated with some drugs, in which larger doses of the drug are needed to achieve a given effect when the drug is used for prolonged periods.
Ability to endure large exposures to a substance without an adverse effect; typically, the patient demonstrates decreased sensitivity to subsequent doses of the same substance. Clinically, patients may develop tolerance to a medication, so that it no longer has the desired effect at the usual dose. Similarly, microorganisms may develop tolerance to antibiotics, rendering particular agents useless in treatment.
Progressive decrease in therapeutic effect of a drug or therapy.
The reduction or loss of the normal response to a drug or other substance that usually provokes a reaction in the body. Drug tolerance may develop after taking a particular drug over a long period of time. In such cases increased doses are necessary to produce the desired effect. Some drugs that cause tolerance also cause dependence.
This occurs when the response to a particular amount of a drug or physiological messenger decreases, so that increasingly large doses must be given to produce the same response as before. It is particularly common with certain drug dependencies for example, with morphine or heroin.
Capacity for enduring a large amount of a substance (e.g., food, drug, or poison) without an adverse effect and showing a decreased sensitivity to subsequent doses of the same substance.
Tolerance is the body’s physical adjustment to the habitual use of a chemical.
The ability to overlook differences and to accept people for who they are; also a condition in which a user needs more of a drug to get the same effect.
The condition where more of a drug or activity is required to reproduce the initial sensation.
A reduction in the responsiveness to a drug, referred to as tolerance, wherein an individual requires progressively higher doses of the drug to achieve the same desired effect.
The requirement for progressively larger amounts of a drug to achieve a consistent physical or mental impact is known as tolerance. This tolerance typically develops with prolonged drug use, often arising due to the liver becoming more adept at metabolizing the drug or the body’s tissues becoming less responsive to its effects.
The ability to withstand the effects of a medication, especially when it has been used over an extended period.